GENETIC METHODS FOR EPIDEMIOLOGICAL INVESTIGATIONS: A SYNTHESIS
نویسندگان
چکیده
منابع مشابه
Statistical models for genetic susceptibility in toxicological and epidemiological investigations.
Models are presented for use in assessing genetic susceptibility to cancer (or other diseases) with animal or human data. Observations are assumed to be in the form of proportions, hence a binomial sampling distribution is considered. Generalized linear models are employed to model the response as a function of the genetic component; these include logistic and complementary log forms. Susceptib...
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Introduction Large-scale association studies have been proposed as a promising means of identifying pre-disposing genes in common complex diseases. Genome-wide linkage disequilibrium (LD) mapping of common diseases could be more powerful than linkage analysis if the appropriate density of polymorphic markers were known and if the genotyping effort and costs could be reduced. An obvious choice f...
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Introduction In cross-sectional epidemiological studies, a random sample is usually drawn from the general population in to make conclusions about the underlying general population. This approach assumes that the response probability is the same for all subjects in the population. However, it is known (1) that participants and non-participants differ in terms of their personal and disease-relat...
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BACKGROUND In the last decade, a disorder characterized by episodes of involuntary movements and dystonia has been recognized in Border Terriers. OBJECTIVES To define clinical features of paroxysmal dyskinesia (PD) in a large number of Border Terriers and to study the genetics of the disease. ANIMALS 110 affected and 128 unaffected client-owned Border Terriers. METHODS A questionnaire reg...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 1961
ISSN: 0077-8923
DOI: 10.1111/j.1749-6632.1961.tb31109.x